Possible Interaction: Melatonin and 3-Nitrotyrosine

“However, exogenously given MLT significantly reduced the 3-NT formation as well as prostaglandin (PGE2) levels in the brain.”

“Nevertheless, the activity of superoxide dismutase and catalase, as well as nitrotyrosine and nNOS levels, were altered in the hippocampus following melatonin administration.”

“Oral melatonin significantly reduced mRNA and protein expression of iNOS (P < 0.05 and P < 0.01, respectively), TNFα (P < 0.05), nitrotyrosine (P < 0.05), and MPO activity (P < 0.05) in lung tissues when compared with the sham‐treated animals.”

“Here, our results revealed that daily postburn intraperitoneal melatonin administration at a dose of 1.86 mg/kg (8 μmole/kg) significantly suppressed both neutrophil infiltration and tyrosine nitrosylation as revealed by Gr-1 and nitrotyrosine immunohistochemistry, respectively.”

“Again, melatonin treatment reduced both nitrotyrosine reactivity and tissue damage associated with nicotine administration.”

“However melatonin administration prevented 3‐nitrotyrosine formation while failing to prevent or restore changes in the energy charge ratio of the kidney.”

“Administration of melatonin also markedly reduced the nitrotyrosine and PAR formation.”

“ Melatonin also reduced the appearance of nitrotyrosine and PARS immunoreactivity in the colon, as well as reducing the up‐regulation of ICAM‐1 and the expression of P‐selectin.”

“The degrees of staining for nitrotyrosine and for PARS were markedly reduced in tissue sections obtained from animals that received melatonin.”

“Treatment with melatonin (125 microg/paw) reduced the appearance of nitrotyrosine in the tissues.”