Possible Interaction: Megestrol Acetate and Vitamin C

“As the genotoxic effects of steroids can be … properties, and ascorbic acid possesses antioxidant activity, ascorbic acid (20, 40 or …) administered together with megestrol acetate (32.50 mg/kg of body weight) significantly decreased CAs and SCEs, … acid against megestrol acetate induced genotoxic damage in mice bone marrow cells.”

“The highest protective effect was observed at 60 mg/kg body weight of ascorbic acid treated with 32.50 mg/kg body weight of megestrol acetate.”