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Last Updated: 2 years ago

Possible Interaction: Megestrol Acetate and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

ResultsCompared to placebo, acute administration of megestrol resulted in a significant decrease in morning ACTH and cortisol levels.
The suppression of ACTH after pretreatment with megestrol was less pronounced than after pretreatment with hydrocortisone.
Cancer Chemotherapy and Pharmacology  •  2003  |  View Paper
Megestrol acetate administration was associated with profound suppression of ACTH and cortisol levels.
Cancer Chemotherapy and Pharmacology  •  2002  |  View Paper
Megestrol acetate did not suppress the secretion of pituitary sex hormones, but in 3 of 10 patients studied was found inhibition of ACTH secretion.
Megestrol acetate may induce hyperglycaemia and inhibit the secretion of ACTH in some patients.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia  •  2010  |  View Paper
Baseline ACTH and cortisol levels, as well as ACTH and cortisol levels after administration of CCK‐4, were significantly reduced after pretreatment with megestrol.
Depression and anxiety  •  2006  |  View Paper
Discussion The cortisol and ACTH levels of our prospectively studied patients decreased significantly while these patients were receiving megestrol acetate.
Annals of Internal Medicine  •  1995  |  View Paper
Megestrol acetate inhibited both the release and total ACTH content of the anterior pituitary gland, while RU 38486 increased both the release and the total ACTH content.
Cancer research  •  1985  |  View Paper
Administration of megestrol acetate suppressed the total content and the ability to release PRL, ACTH and LH of the pituitary gland of tumor bearing rats.
European journal of cancer & clinical oncology  •  1981  |  View Paper