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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Megestrol Acetate and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

ResultsCompared to placebo, acute administration of megestrol resulted in a significant decrease in morning ACTH and cortisol levels.
The suppression of ACTH after pretreatment with megestrol was less pronounced than after pretreatment with hydrocortisone.
Cancer Chemotherapy and Pharmacology  •  2003  |  View Paper
Baseline ACTH and cortisol levels, as well as ACTH and cortisol levels after administration of CCK-4, were significantly reduced after pretreatment with megestrol.
Depression and anxiety  •  2006  |  View Paper
Administration of megestrol acetate also produced a progressive decrease in both resting plasma cortisol concentrations and cortisol concentrations after ACTH stimulation.
Research in veterinary science  •  1987  |  View Paper
Megestrol acetate inhibited both the release and total ACTH content of the anterior pituitary gland, while RU 38486 increased both the release and the total ACTH content.
Cancer research  •  1985  |  View Paper