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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Megestrol Acetate
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ResultsCompared to placebo, acute administration of megestrol resulted in a significant decrease in morning ACTH and cortisol levels.”
“The suppression of ACTH after pretreatment with megestrol was less pronounced than after pretreatment with hydrocortisone.”
Acute effects of megestrol on the hypothalamic–pituitary–adrenal axis“ Megestrol acetate administration was associated with profound suppression of ACTH and cortisol levels.”
“ Megestrol acetate did not suppress the secretion of pituitary sex hormones, but in 3 of 10 patients studied was found inhibition of ACTH secretion.”
“ Megestrol acetate may induce hyperglycaemia and inhibit the secretion of ACTH in some patients.”
“Baseline ACTH and cortisol levels, as well as ACTH and cortisol levels after administration of CCK‐4, were significantly reduced after pretreatment with megestrol.”
“Discussion The cortisol and ACTH levels of our prospectively studied patients decreased significantly while these patients were receiving megestrol acetate.”
“ Megestrol acetate inhibited both the release and total ACTH content of the anterior pituitary gland, while RU 38486 increased both the release and the total ACTH content.”
Comparison of the actions of RU 38486 and megestrol acetate in the model of a transplantable adrenocorticotropin- and prolactin-secreting rat pituitary tumor.“Administration of megestrol acetate suppressed the total content and the ability to release PRL, ACTH and LH of the pituitary gland of tumor bearing rats.”
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