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Discover Supplement-Drug Interactions

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Last Updated: 5 years ago

Possible Interaction: Mefloquine and Quinine

drug:

Mefloquine

supplement:

Quinine

Research Papers that Mention the Interaction

“Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine.”
Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.
British medical journal  •  1977  |  View Paper
“ Mefloquine and quinine both showed synergism of artesunate activity against each of the strains, whilst doxycycline showed an additive interaction.”
The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro.
Transactions of the Royal Society of Tropical Medicine and Hygiene  •  1999  |  View Paper
“ Mefloquine and quinine , the only antimalarials generally available for the treatment of highly drug-resistant P. falciparum in pregnancy, give unsatisfactory treatment responses when used as single agents.”
Quinine and mefloquine in the treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy.
Annals of tropical medicine and parasitology  •  1998  |  View Paper
“A significant positive correlation was found between responses to quinine and mefloquine.”
Drug sensitivity of Plasmodium falciparum in Gabon. Activity correlations between various antimalarials.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit  •  1994  |  View Paper
“Throughout this adaptation, the 50% inhibitory concentration for chloroquine and quinine showed no modification, but it increased considerably for mefloquine , exceeding known levels of resistance.”
Mefloquine-halofantrine cross-resistance in Plasmodium falciparum induced by intermittent mefloquine pressure.
The American journal of tropical medicine and hygiene  •  1992  |  View Paper
“The parasite was susceptible to chloroquine and quinine in vitro but displayed elevated values of 50% inhibitory concentration for mefloquine and halofantrine.”
Type RI resistance to halofantrine in West Africa.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit  •  1991  |  View Paper
“However, limited availability of quinine and increasing resistance to mefloquine restrict these options.”
Updated CDC Recommendations for Using Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria in Pregnant Women in the United States
MMWR. Morbidity and mortality weekly report  •  2018  |  View Paper
“With quinine , because peak plasma concentrations are very close to the Ki value, there is likely to be inhibition of mefloquine metabolism in patients receiving both drugs.”
Mefloquine metabolism by human liver microsomes. Effect of other antimalarial drugs.
Biochemical pharmacology  •  1992  |  View Paper
“The results suggest the presence of strong interactions between mefloquine and quinine with lipid bilayers, especially with the PE component.(ABSTRACT TRUNCATED AT 250 WORDS)”
A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with lipids extracted from normal human erythrocytes.
Molecular and biochemical parasitology  •  1990  |  View Paper
“The existence of correlation of sensitivity to mefloquine and quinine was detected and discussed.”
In vitro sensitivity of Plasmodium falciparum isolates from Burma to chloroquine quinine and mefloquine.
The Southeast Asian journal of tropical medicine and public health  •  1985  |  View Paper
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