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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Mefloquine and Quinine

supplement:

Quinine

Research Papers that Mention the Interaction

Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine.
British medical journal  •  1977  |  View Paper
Mefloquine and quinine both showed synergism of artesunate activity against each of the strains, whilst doxycycline showed an additive interaction.
Transactions of the Royal Society of Tropical Medicine and Hygiene  •  1999  |  View Paper
Mefloquine and quinine , the only antimalarials generally available for the treatment of highly drug-resistant P. falciparum in pregnancy, give unsatisfactory treatment responses when used as single agents.
Annals of tropical medicine and parasitology  •  1998  |  View Paper
A significant positive correlation was found between responses to quinine and mefloquine.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit  •  1994  |  View Paper
Throughout this adaptation, the 50% inhibitory concentration for chloroquine and quinine showed no modification, but it increased considerably for mefloquine , exceeding known levels of resistance.
The American journal of tropical medicine and hygiene  •  1992  |  View Paper
The parasite was susceptible to chloroquine and quinine in vitro but displayed elevated values of 50% inhibitory concentration for mefloquine and halofantrine.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit  •  1991  |  View Paper
However, limited availability of quinine and increasing resistance to mefloquine restrict these options.
MMWR. Morbidity and mortality weekly report  •  2018  |  View Paper
With quinine , because peak plasma concentrations are very close to the Ki value, there is likely to be inhibition of mefloquine metabolism in patients receiving both drugs.
Biochemical pharmacology  •  1992  |  View Paper
The results suggest the presence of strong interactions between mefloquine and quinine with lipid bilayers, especially with the PE component.(ABSTRACT TRUNCATED AT 250 WORDS)
Molecular and biochemical parasitology  •  1990  |  View Paper
The existence of correlation of sensitivity to mefloquine and quinine was detected and discussed.
The Southeast Asian journal of tropical medicine and public health  •  1985  |  View Paper
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