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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mefloquine
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“Because mefloquine is a Cationic amphiphilic drug and is known to insert into lipid bilayers, we postulate that mefloquine interferes with the interaction between PIP2 and Kir channels resulting in channel inhibition.”
“In inside-out patches, continuous application of PIP2 strikingly prevented the mefloquine inhibition.”
The Antimalarial Drug Mefloquine Inhibits Cardiac Inward Rectifier K+ Channels: Evidence for Interference in PIP2-Channel Interaction
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