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Last Updated: 2 years ago

Possible Interaction: Medroxyprogesterone Acetate and Apigenin

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drug:

Medroxyprogesterone Acetate

supplement:

Apigenin

Research Papers that Mention the Interaction

“ Apigenin was more potent than other polyphenols in increasing the levels of pregnenolone and 17α-hydroxyprogesterone , suggesting that it inhibits cytochrome P450 (CYP) 17 and CYP21, as well as 3β-HSD.”

Effect of polyphenols on production of steroid hormones from human adrenocortical NCI-H295R cells.

Biological & pharmaceutical bulletin • 2013 | View Paper

“However, the number of progesterone receptor–positive cells was reduced in animals treated with MPA or MPA and apigenin compared with those treated with placebo.”

Apigenin Prevents Development of Medroxyprogesterone Acetate-Accelerated 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Sprague–Dawley Rats

Cancer Prevention Research • 2011 | View Paper

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