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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Mechlorethamine
drug:
Vincristine
Research Papers that Mention the Interaction
“A retrospective analysis of prognostic factors in 192 patients with Hodgkin lymphoma (… over a 20-year period at the NCI with MOPP nitrogen mustard , vincristine, procarbazine, prednisone) regimen suggested that … lower percent-projected rate of vincristine administered over six cycles was associated with … inferior complete remission (CR) rate [5].”
The justification of vincristine dose capping: tradition, tradition…tradition!“Addition of vincristine (an inhibitor of microtubule polymerization) in the presence of HN2 also decreased the cytotoxic effect of HN2.”
Modulation of the cellular toxicity of nitrogen mustard in murine cells.
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