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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Mechlorethamine
drug:
Romidepsin
Research Papers that Mention the Interaction
“Consistently, the combination of mechlorethamine plus romidepsin resulted in downregulation of STAT5 phosphorylation in romidepsin-sensitive cell lines and primary SS samples, but not in romidepsin-resistant tumors.”
“Here, we show synergistic anti-lymphoma effects of romidepsin in combination with mechlorethamine , an alkylating agent, in CTCL cell lines and primary samples with strong antitumor effects in an in vivo model of SS.”
“Overall, these results support a role for romidepsin plus mechlorethamine in combination in the treatment of CTCL and uncover a previously unrecognized role for JAK-STAT signaling in the response to romidepsin and romidepsin-based combination therapies in SS.”
83JAK-STAT inhibition mediates romidepsin and mechlorethamine synergism in Cutaneous T-cell Lymphoma.
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