Possible Interaction: Mechlorethamine and Procarbazine

“After treatment with more than six cycles of combinations including procarbazine and mechlorethamine , the risk of leukemia was 14-fold higher than after radiotherapy alone.”

“Especially high risks were observed among patients receiving ≥8400 mg/m(2) of procarbazine with nitrogen mustard or ≥3900 mg/m(2) of cyclophosphamide.”

“Addition of HN2 and PCZ , chemotherapeutic agents active against NSCLC, failed to improve the tumor response rate but added to gastrointestinal and hematologic toxicity.”

“Among patients treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP), risk increased with cumulative amounts of mechlorethamine and procarbazine (P<.001) when evaluated separately.”

“As compared with patients who received RT alone, … with six or fewer cycles of combinations including nitrogen mustard (mechlorethamine) … procarbazine had an eightfold increased risk of developing leukemia (P = .08), while patients who received more … six of such cycles had a greater than 40-fold excess risk (P < .001).”

“ Nitrogen mustard and procarbazine used clinically as single drugs are given in three and two times, respectively, greater doses than in the combined regimen.”

“ Nitrogen mustard and procarbazine , administered as single drugs in high doses, were highly suppressive, resulting in only 10–19% survival of CFU/femur, whereas, reduced doses of the two drugs as used in the MOPH regimen spared 30–45% of the CFU/femur.”