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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Mechlorethamine and Procarbazine

Research Papers that Mention the Interaction

After treatment with more than six cycles of combinations including procarbazine and mechlorethamine , the risk of leukemia was 14-fold higher than after radiotherapy alone.
The New England journal of medicine  •  1990  |  View Paper
Especially high risks were observed among patients receiving ≥8400 mg/m(2) of procarbazine with nitrogen mustard or ≥3900 mg/m(2) of cyclophosphamide.
Annals of oncology : official journal of the European Society for Medical Oncology  •  2014  |  View Paper
Addition of HN2 and PCZ , chemotherapeutic agents active against NSCLC, failed to improve the tumor response rate but added to gastrointestinal and hematologic toxicity.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
Among patients treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP), risk increased with cumulative amounts of mechlorethamine and procarbazine (P<.001) when evaluated separately.
Journal of the National Cancer Institute  •  2002  |  View Paper
As compared with patients who received RT alone, … with six or fewer cycles of combinations including nitrogen mustard (mechlorethamine) … procarbazine had an eightfold increased risk of developing leukemia (P = .08), while patients who received more … six of such cycles had a greater than 40-fold excess risk (P < .001).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology  •  1994  |  View Paper
Nitrogen mustard and procarbazine used clinically as single drugs are given in three and two times, respectively, greater doses than in the combined regimen.
Nitrogen mustard and procarbazine , administered as single drugs in high doses, were highly suppressive, resulting in only 10–19% survival of CFU/femur, whereas, reduced doses of the two drugs as used in the MOPH regimen spared 30–45% of the CFU/femur.
American journal of hematology  •  1976  |  View Paper