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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Mechlorethamine
supplement:
Ebselen
Research Papers that Mention the Interaction
“Significant increases in cell … demonstrated when 30μM Eb … HN2 in all cell models tested at the following doses of HN2: A431 skin cells,10—40μM; rat astrocytes, 20 and … cells 4—16 μM. Decreases in cell viability and toxicity to HN2 were confirmed using light and scanning electron microscopy.”
Ebselen protects brain, skin, lung and blood cells from mechlorethamine toxicity“In vivo, ebselen also had a marked protective effect against spleen weight loss associated with lymphocyte apoptosis in mice treated by HN2.”
“We examined whether ebselen would inhibit apoptosis in BALB/c mouse spleen lymphocytes and human MOLT-4 leukemia cells treated with HN2 (2.5 microM) in vitro.”
“Significant increases in caspase 3 and caspase 9 activities were observed in response to HN2 , and ebselen was found to reduce these effects.”
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