supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
drug:
Mecamylamine
supplement:
Niacin
Research Papers that Mention the Interaction
“ Abstract Mecamylamine is an antihypertensive that acts via nicotinic antagonism and has been suggested as an aid in smoking cessation.”
Mecamylamine does not precipitate withdrawal in cigarette smokers“On the other hand, the choice accuracy deficit induced by nicotinic blockade with mecamylamine is potentiated by haloperidol.”
“This protective effect was completely reversed when nicotinic and melatonin receptors were blocked respectively by mecamylamine and luzindole.”
“The nicotinic current triggered a depolarization event with a peak at +49.3 mV and a ‘plateau’ phase that ended at −23.9 mV, which was blocked by 10 μmol/L mecamylamine.”
“On the other hand, a 3-mM concentration of the nicotinic ACh antagonist mecamylamine decreased spike firing of these interneurons.”
Cholinergic Neurotransmission from Mechanosensory Afferents to Giant Interneurons in the Terminal Abdominal Ganglion of the Cricket Gryllus bimaculatus“Chlorisondamine and mecamylamine are nicotinic antagonists that produce both ganglionic and central blockade.”
“The release was completely blocked by nicotinic antagonists hexamethonium (100 μmol/l) and mecamylamine (10 μmol/l), and decreased by tetrodotoxin (0.3 μmol/l) and ω-conotoxin (0.1 μmol/l) to 17% and 27%, resp.”
“Systemic injections of nicotinic blocking drugs such as dihydro-β-erytroidin or mecamylamine decrease or suppress the occurrence of RR; therefore, cholinergic synapses are involved in the RR generating process.”
“The nicotinic responses of cultured neurons were found to be blocked by mecamylamine and curare but highly resistant to alpha-bungarotoxin.”
“ Mecamylamine , a broad‐spectrum nicotinic antagonist, reversibly inhibited nicotinic action.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback