“ Mecamylamine , a nicotinic acetylcholine receptor (nAChR) antagonist, totally abolished the inhibitory effects of huperzine A on ischemia‐induced glial cells activation.”
“…,mecamylamine partially reversed the infarct …‐reducing effects of huperzine A. In conclusion, our results demonstrate that huperzine A exhibits neuroprotective effects against transient focal cerebral ischemia‐induced brain injury and suggest that the protection mechanism may involve a cholinergic anti‐inflammatory pathway, in which nAChR plays an essential role.”