Possible Interaction: Masoprocol and Calcium Supplement

“We identified a set of reagents, nordihydroguaiaretic acid and various calmodulin inhibitors, that inhibits Ca2+ entry and blocks the voltage-operable current but leaves the non-voltage-gated current unaltered.”

“Treatments given with NDGA result in the reduction of SCE, CA and increase of MI as well as RI, suggesting its protective action on human lymphocytes in vitro against the norgestrel induced genotoxic damage.”

“We investigated this activity and found that NDGA prevented the rise in intracellular calcium necessary for the apoptotic activation of cPLA(2).”

“Enhancements of IM by Ca2+ and AA were blocked by the lipoxygenase (LO) inhibitors nordihydroguaiaretic acid (NDGA; 1‐5 microM) and 5,8,11‐eicosatrynoic acid (ETI; 10 microM).”

“When high calcium was applied in the presence of 100 microM NDGA , induction of potentiation in the dentate gyrus was blocked, while in CA1 there was an initial potentiation which was not maintained on return to control medium.”

“The results demonstrated that the intracranial pressure, water content, and sodium and calcium but not potassium content were significantly decreased in cerebral edema tissue but only 48 h after pretreatment with indomethacin (10 mg/kg), nordihydroguaiaretic acid (3 mg/kg) or their combination in half doses.”