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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Several case reports show cannabis may inhibit the metabolism of warfarin because of CYP2C9 interactions, resulting in increased plasma concentrations, increased international normalized ratio, and risk of bleeding.”
A Review of Cannabis and Interactions With Anticoagulant and Antiplatelet Agents“Some of them receive medications with known potential negative interactions with cannabis , such as THC-mediated increase in bleeding time in patients using warfarin (10).”
“Until further data are available, we suggest patients receiving warfarin be warned against cannabis use.”
“Discussion: The elevation in INR can be explained by the inhibition of CYP2C9 by cannabis use causing decreased metabolism of warfarin.”
“The INR dropped below 4 upon discontinuation of cannabis with dose adjustments to warfarin.”
“Discussion: Marijuana may increase warfarin anticoagulant effect by inhibiting its metabolism, and to a lesser extent, displacing warfarin from protein-binding sites.”
“He was counseled by the pharmacist on the potential interaction of warfarin and marijuana.”
“Among thirty-eight herbs, Cannabis , Chamomile, Cranberry, Garlic, Ginkgo, Grapefruit, Lycium, Red clover, and St. John's wort were evaluated to have major severity interaction with warfarin.”
Updates on the Clinical Evidenced Herb-Warfarin Interactions
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