Possible Interaction: Marijuana and Tetrahydrocannabinol (THC)

“There is … laboratories, that marihuana … A!’-tetrahydrocannabinol ( A9-THC), its major psychoactive component, produce CNS depression, and that an interaction occurs between these drugs and the Since no … barbiturates, we embarked on a clinical study to investigate whether these interactions occurred in man, and to determine their clinical significance.”

“10 It is suggested that there may be potentiation of the effects of Δ9‐THC by other substances present in these marihuana samples.”

“Pretreatment with oral THC (10-mg and/or 20-mg vs. placebo) significantly attenuated marijuana cue-induced increases in craving and anxiety but not hunger.”

“Results of this study suggest oral THC may be effective for reducing marijuana cue-elicited (conditioned) effects.”

“Those smoking higher CBD : THC strains also showed lower self-rated liking of cannabis stimuli on both test days.”

“Results:As compared with placebo, marijuana and dronabinol dose dependently increased daily caloric intake and body weight in HIV-positive marijuana smokers.”

“ Oral THC administered during marijuana abstinence decreased ratings of ‘anxious’, ‘miserable’, ‘trouble sleeping’, ‘chills’, and marijuana craving, and reversed large decreases in food intake as compared to placebo, while producing no intoxication.”

“Thus, oral THC decreased marijuana craving and withdrawal symptoms at a dose that was subjectively indistinguishable from placebo.”

“RATIONALE There has been controversy about whether the subjective, behavioral or therapeutic effects of whole plant marijuana differ from the effects of its primary active ingredient, Delta(9)-tetrahydrocannabinol (THC).”

“These results support the hypothesis that the reinforcing effects of marijuana , and possibly its abuse liability, are positively related to THC content.”

“Twenty–seven days exposure of 10 male volunteers to marijuana cigarettes containing a total dose of 16 mg of Δ9–tetrahydrocannabinol resulted in a significant reduction in the effect of the drug on heart rate.”

“WE HAVE recently reported that marihuana extract , calibrated for content of (—)-Δ1-tetrahydrocannabinol ( THC), significantly impaired the serial coordination of cognitive operations during a task that required sequential adjustments in reaching a goal.1Our term for this mental incoordination is temporal disintegration.”