Possible Interaction: Marijuana and Nabiximols

“The combination of Sativex and MET/CBT reduced the amount of cannabis use and progressively reduced craving and withdrawal scores.”

“Researchers reported that patients who were treated for 12 weeks with nabiximols significantly reduced the number of days on which they used cannabis (18.6 days less compared to placebo users; 95% CI: 3.5-33.7).”

“RESULTS A … na iximols group us … nabis on 6.8 fewer days in the previous 28 days at week 12 (end of treatment) than the placebo group (p = 0.002, … the previous 28 days at the week-24 follow-up than the placebo group (p = 0.006, CI: 1.4,12.1).”

“ Cannabis use was reduced in the nabiximols (70.5%) and placebo groups (42.6%).”

“ Nabiximols reduced cannabis craving but no significant differences between the nabiximols and placebo groups were observed on withdrawal scores.”

“We previously showed that nabiximols (27 mg/ml Δ9-tetrahydrocannabinol (THC)/ 25 mg/ml cannabidiol (CBD), Sativex®) can decrease cannabis withdrawal symptoms.”

“BackgroundThe cannabis extract nabiximols (Sativex®) effectively supresses withdrawal symptoms and cravings in treatment resistant cannabis dependent individuals, who have high relapse rates following conventional withdrawal treatments.”

“CONCLUSIONS AND RELEVANCE In a treatment-seeking cohort, na iximols at tenuated can nabis wi thdrawal symptoms and improved patient retention in treatment.”

“RESULTS Na iximols tr eatment significantly reduced the overall severity of can nabis wi thdrawal relative to placebo (F8,377.97 = 2.39; P = .01), including effects on withdrawal-related irritability, depression, and cannabis cravings.”

“ Sativex was shown to have low abuse potential when administered in supratherapeutic doses to recreational marijuana users [6]; it is expected that the abuse potential would be even less when doses are distributed evenly throughout the day [6].”