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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Marijuana and Gabapentin

supplement:

Marijuana

Research Papers that Mention the Interaction

Relative to placebo, gabapentin significantly reduced cannabis use as measured both by urine toxicology (p=0.001) and by the Timeline Followback Interview (p=0.004), and significantly decreased withdrawal symptoms as measured by the Marijuana Withdrawal Checklist (p<0.001).
Neuropsychopharmacology  •  2012  |  View Paper
Participants reporting gabapentin misuse had higher odds of reporting (mis)use of marijuana , cocaine, methamphetamine, prescription opioids, benzodiazepines, prescription stimulants, fentanyl, and buprenorphine (p < .042); severe substance use disorder (p < .000); and recent physical pain (p < .003).
Substance use & misuse  •  2020  |  View Paper
No medications are approved for cannabis use disorder (CUD), though a small clinical trial demonstrated that the voltage-dependent calcium channel (VDCC) ligand gabapentin reduced cannabis use in treatment seekers.
Experimental and clinical psychopharmacology  •  2021  |  View Paper
Some drugs, such as CB1 agonists, gabapentin , and N-acetylcysteine, have been shown to produce improvements in some symptoms of CUD in single studies, but these have not been replicated.
F1000Research  •  2018  |  View Paper