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“During placebo marijuana smoking, i.e., active marijuana withdrawal, ratings of irritability, restlessness, depression, and trouble sleeping were increased by bupropion compared to placebo maintenance.”
“ConclusionsDopamine release and/or inhibition of dopamine transport blocks detection of Δ9-THC and is potentially the mechanism by which some therapeutics (e.g., bupropion ) reduce the subjective effects of marijuana and enhance the subjective effects of marijuana withdrawal.”