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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Maprotiline
supplement:
Yohimbine
Research Papers that Mention the Interaction
“Finally, we tried …-inflammatory effect of maprotiline by propranolol (10 mg … mg kg−1), yohimbine (10 mg kg−1), naloxone (4 mg kg−1) and mifepristone (5 mg kg−1).ResultsSystemic, intracerebroventricular … of maprotiline significantly inhibited peripheral edema, but intrathecal maprotiline did not alter the degree of paw swelling.”
Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats“Coadministration of maprotiline increased the antinociceptive duration of morphine by 4-fold (from 120 to 480 min), which was reversed by pretreatment with the α-2 adrenoceptor inhibitor, yohimbine , and the mu-type opioid receptor antagonist, naloxone.”
“Dothiepin and mianserin (16 and 32 mg/kg), fluoxetine (32 and 64 mg/kg), maprotiline and imipramine (16, 32 and 64 mg/kg) and viloxazine (16 mg/kg) significantly potentiated mortality following acute administration with yohimbine.”
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