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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Manidipine and Grapefruit Extract

Research Papers that Mention the Interaction

As most of the 1,4-dihydropyridine calcium channel blockers are metabolized by cytochrome P450 (CYP) 3A4, it is not surprising that grapefruit juice should inhibit the intestinal metabolism of manidipine.
British journal of clinical pharmacology  •  2006  |  View Paper