Possible Interaction: Manganese and Vitamin E

“Administration of an antioxidant, such as vitamin E , also partially prevented striatal dopamine decline induced by intranigral manganese infusion.”

“It was noted that the amounts of α-tocopherol were elevated in both the Mn and Cr complex groups compared to control group.”

“Pretreatment with nitric oxide blocker (7-nitroindazole, 7-NI), vitamin E or NF-kappaB inhibitor (SN50) significantly protected the cells from Mn and DA interaction-induced reactive oxygen species (ROS) and apoptosis.”

“Pretreatment of astrocyte … antioxidants, including vitamin E , the spin trapping agent PBN, and the iron-chelating agent desferroximine, as well as the … oxide synthase inhibitor l-NAME, all significantly blocked (50-80%) astrocyte swelling caused by manganese , suggesting that oxidative/nitrosative stress is … in the mechanism of such swelling.”

“In the cortex, vitamin E completely prevented a decrease in enzyme activity for Cu/Zn superoxide dismutase and catalase, and partly for Mn superoxide dismutase and glutathione peroxidase.”

“Egg yolk concentrations of Zn, Fe, and Mn decreased under high environmental temperature and were increased to values of the control group (P=0.001) when dietary vitamin E was supplemented.”