Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Manganese and Uridine Triacetate

Research Papers that Mention the Interaction

Mn exposure may produce the reduction of BF cholinergic neurons by increasing amyloid beta (Aβ) and phosphorylated Tau (pTau) protein levels, altering heat shock proteins' (HSPs) expression, disrupting proteasome P20S activity and generating oxidative stress.
Ecotoxicology and environmental safety  •  2020  |  View Paper
Importantly, we found that transplantation of gut microbiota from normal rats into Mn exposure rats reduced Aβ and Tau expression, and the cerebral expression of NLRP3 was downregulated, and the expression of neuroinflammatory factors was also downregulated.
In this study, we found that Mn exposure increases Aβ1-40 and Tau production in brain, and causes hippocampal degeneration and necrosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2020  |  View Paper
In our present research, treatment of cells with manganese increased the phosphorylation of tau at Ser199, Ser202, Ser396, and Ser404 as detected by Western blot.
Taken together, we found for the first time that the exposure to manganese can cause the hyperphosphorylation of tau , which may be connected with the activation of ERK MAPK.
Toxicological sciences : an official journal of the Society of Toxicology  •  2011  |  View Paper
Pretreatment with MK-801, Tau and DM can antagonize neurotoxicity induced by manganese in the certain extent.
Toxicology and industrial health  •  2010  |  View Paper