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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Manganese
drug:
Uridine Triacetate
Research Papers that Mention the Interaction
“ Mn exposure may produce the reduction of BF cholinergic neurons by increasing amyloid beta (Aβ) and phosphorylated Tau (pTau) protein levels, altering heat shock proteins' (HSPs) expression, disrupting proteasome P20S activity and generating oxidative stress.”
“Importantly, we found that transplantation of gut microbiota from normal rats into Mn exposure rats reduced Aβ and Tau expression, and the cerebral expression of NLRP3 was downregulated, and the expression of neuroinflammatory factors was also downregulated.”
“In this study, we found that Mn exposure increases Aβ1-40 and Tau production in brain, and causes hippocampal degeneration and necrosis.”
“In our present research, treatment of cells with manganese increased the phosphorylation of tau at Ser199, Ser202, Ser396, and Ser404 as detected by Western blot.”
“Taken together, we found for the first time that the exposure to manganese can cause the hyperphosphorylation of tau , which may be connected with the activation of ERK MAPK.”
Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells.“Pretreatment with MK-801, Tau and DM can antagonize neurotoxicity induced by manganese in the certain extent.”
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