Possible Interaction: Manganese and Tyrosine

“The production of Tyr during 12h incubation in B (183.6 μmol/g MN ) was 4.3 times higher than that in P. One of the intermediate products between Phe and Tyr seems to bep-hydroxyphenylacetic acid.”

“In addition, manganese induces phosphorylation of c‐Jun at Ser63 and Ser73 and SEK1/MKK4 (c‐Jun N‐terminal kinase kinase) at Thr258 and tyrosine phosphorylation of several proteins.”

“ Manganese treatment produced an initial increase in the contents of dopamine (DA), norepinephrine (NE), homovanillic acid (H VA) and tyrosine in the corpus striatum.”

“Marked alterations in the contents of tyrosine , tryptophan, dopamine, and norepinephrine in the brain tissue of rats after the combined treatment with immobilization and manganese suggested that the neurotoxic effects of the metal may be more pronounced in a stressful situation.”

“The levels of striatal tyrosine , homovanillic acid and manganese were also significantly increased in mice after manganese exposure.”

“Oxidation of the tyrosine by P(680)(+) repels protons to and out from the Mn cluster.”

“A possible explanation of this block or dramatic decrease in the rate of electron transfer between the manganese cluster and tyrosine Z is an alteration in the properties of the metal center.”