Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Manganese and Thiamine

supplement:

Manganese

supplement:

Thiamine

Research Papers that Mention the Interaction

Addition of manganese to the diets promotes an increase of the total thiamine content in the blood and the liver, heart and brain tissues.
Voprosy pitaniia  •  1980  |  View Paper
Similar antagonism, with respect to the toxicities of manganese and thiamine had been reported earlier by Perla and associates (Perla, '39; Perla and Sandberg, '39; Perla, Sandberg and Holly, '39; Sandberg, Perla and Holly, '39).
The investigation of body-temperature control (Hill and Holtkamp, '48) showed thiamine in low concentrations to be antagonistic to low con centrations of manganese.
The Journal of nutrition  •  1954  |  View Paper
Optimal activation is obtained with concentrations of 2·10-2 M. Low concentrations of Mn also activate the enzyme, even more so than comparable amounts of Mg; but concentrations of Mn above 2·10-3 M markedly inhibit the phosphorylation of thiamine.
Biochimica et biophysica acta  •  1952  |  View Paper