Possible Interaction: Manganese and Taurine

“Our results support that taurine improves the impaired learning and memory ability caused by excessive exposure of manganese.”

“150 and 200 mg/kg of taurine could decrease apoptosis index of the group exposed to 10、15、20 mg/kg of Mn (P<0.05) .”

“Conclusion: Mn could cause cell cycle arrest to S, increase level of apoptosis in striatum, to a certain extent, taurine can protect neurons from apoptosis induced by Mn.”

“These data suggest mitochondrial protection as an underlying mechanism for the protective effects of taurine against Mn toxicity.”

“Antioxidative and mitochondria protecting effects of taurine might play a fundamental role in its neuroprotective properties against Mn toxicity.”

“150 and 200 mg/kg of taurine could decrease active calmodulin content of the group exposed to 10 mg/kg of Mn (P<0.05) .”

“150 and 200 mg/kg of taurine could respectively improve activities of Ca(2+)-Mg(2+)-ATPase of the group exposed to 15, 10 mg/kg of Mn (P<0.05) .”

“150 mg/kg of taurine could increase activities of Na(+)-K(+)-ATPase of the group exposed to 10 mg/kg of Mn (P<0.05) .”

“Results: The corpus striatum Mn content of the 3 dose groups exposed to Mn and 9 taurine intervened groups were significantly higher than that of the control group (P<0.05) .”

“…:Mn can decrease the rats corpus striatum activities of Na(+)-K(+)-ATPase and Ca(2+)-Mg(… level of active calmodulin in relation to dose of Mn, to a certain extent, taurine could regulate activities of Na(+)-K(+)-ATPase and Ca(…(2+)-ATPase and improve the level of active calmodulin.”

“ Manganese concentrations increased in the striatum, the rest of the brain, and in plasma, and regional brain neurotransmitter concentrations, including noradrenaline, dopamine (DA), 5-hydroxytrytamine, glutamate, taurine , and γ-amino butyric acid, and the activity of acetylcholinesterase changed.”

“ Mn blunted this response and nearly abolished extracellular taurine throughout collection.”

“These data suggest that Mn increases GABA(EC) by inhibiting the function of GAT, and that perturbed taurine homeostasis potentially impacts neural function by jeopardizing the osmoregulatory and neuromodulatory functions of taurine in the brain.”

“The main mechanisms of Tau preventing cytotoxicity against Mn is the reduction of the oxidative stress in prefrontal cortex neurons.”

“ Taurine (20 mM) was found to decrease significantly ferric iron (50–500 μM)- and manganese (10 μM)-stimulated L-dopa or dopamine oxidation.”