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Last Updated: 2 years ago

Possible Interaction: Manganese and Spiperone

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supplement:

Manganese

drug:

Spiperone

Research Papers that Mention the Interaction

“Chronic treatment of rats with manganese (1 mg MnCl2 X 4H2O per ml of drinking water) from conception till adulthood only slightly decreased [3H]spiperone binding in striatal membranes whereas [3H]quinuclidinyl benzilate binding was not affected.”

[3H]spiperone and [3H]quinuclidinyl benzilate binding in striatal membranes from rats chronically treated with manganese chloride throughout development and for over two years.

General pharmacology • 1986 | View Paper

“Neonatal exposure to manganese (10 mg/kg X 15) produces a decrease in binding of [3H]-spiroperidol to striatal membranes and of serotonin to frontal cortical membranes.”

Neurotransmitters and neurotransmitter receptors in developing and adult rats during manganese poisoning.

Neurotoxicology • 1984 | View Paper

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