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Last Updated: 2 years ago

Possible Interaction: Manganese and Quercetin

supplement:

Manganese

supplement:

Quercetin

Research Papers that Mention the Interaction

QCT lowered the Mn elevated levels of various downstream apoptotic markers, including Bax, cytochrome c, cleaved caspase-3 and polymerase-1 (PARP-1), while QCT treatment upregulated anti-apoptotic Bcl-2 proteins and prevented Mn-induced neurodegeneration.
The … that Mn treatment significantly decreased the cell viability of SK-N-MC cell … the release of lactate dehydrogenase (LDH), which was attenuated by QCT pretreatment at 10 and 20 µg/mL. Compared to the Mn alone …, QCT pretreatment significantly attenuated Mn-induced oxidative stress, mitochondrial dysfunction and apoptosis.
These results indicate that QCT could effectively inhibit Mn induced apoptosis and inflammatory response in SK-N-MC cells and SD rats, which may involve the activation of HO-1/Nrf2 and inhibition of NF-κB pathway.
International journal of molecular sciences  •  2017  |  View Paper
Protein concentration of the different antioxidant enzymes was generally reduced by kaempferol and quercetin in comparison to CM, although quercetin 25 and 50 microM increased Mn SOD protein concentration.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2008  |  View Paper
Quercetin in a concentration range from 5 to 100 µM decreased manganese superoxide dismutase, glutathione peroxidase, and copper zinc superoxide dismutase mRNA expression levels each by 30–40% in rat hepatoma H4IIE cells.
Archives of Toxicology  •  2003  |  View Paper
The flavones morin and quercetin interfered with both Mn and Zn accumulation, which resulted in growth improvement, but supplemental Mn and especially Zn turned the initially benefic action of morin and quercetin into potential toxicity.
Biomolecules  •  2020  |  View Paper