Possible Interaction: Manganese and Potassium

“On the contrary, potassium and manganese concentration decreased.”

“In the isolated vas deferens of the guinea pig, the inhibitory effects of manganese (Mn2+) on the contractions induced by potassium (K+) were decreased when the contractions were induced repeatedly in the presence of Mn2+.”

“However, the depolarization induced by a high potassium dose (30 mM) was accompanied by MPF and MN decrease.”

“The activation curve of the late potassium current is shifted in a depolarizing direction by addition of manganese ions.”

“In 10 mM-Mn Ringer's solution, membrane potential of the semitendinosus muscle fibre was increased by 9.1 mV and the hyperpolarizing action of Mn was observed in various concentrations of potassium up to 50 mM. 4.”

“ Mn suppressed potassium contractures induced by 80 mM-K or less (constant [K] x [Cl] product).”

“ Potassium also increases the maximal velocity of ATPase activated by Mn ’ and Co’, but not Ca’�.”

“Both the spontaneous activity and the potassium contracture are depressed by several transition metal ions such as manganese , nickel, cobalt or iron.”

“Magnesium or manganese was prerequisite for the activity, which was enhanced by ~ 70% in the presence of potassium.”

“We also identified exchangeable potassium as an additional strong predictor, however strongly correlated with manganese.”

“This is likely due to the fact that potassium ions in the lithium layer could weaken the formation of trivacancies in lithium layer and Mn migration to form spinel structure, and that the large ionic radius of potassium could possibly aggravate steric hindrance for spinel growth.”