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Possible Interaction: Manganese and Nitric Oxide



Research Papers that Mention the Interaction

During pathological conditions, such as manganese intoxication, NO production is increased, leading to an increase in LHRH secretion that can advance puberty.
Annals of the New York Academy of Sciences  •  2009  |  View Paper
After cells were treated with 400 μM Mn for 24 h, there were significant increases in production of NO , inducible NO synthase (iNOS) activity, the mRNA and protein expressions of iNOS.
Environmental toxicology  •  2017  |  View Paper
These data indicate that the lower concentration of Mn could cause lower arginase activity and this could also upregulate NO production by increasingl-arginine content in patients with childhood asthma.
Biological Trace Element Research  •  2007  |  View Paper
Mn had a dose- and time-dependent effect on NO content and iNOS activity.
Biological Trace Element Research  •  2015  |  View Paper
Mn exposure also increased the levels of MDA, NO , NOS, DPC, and protein carbonyl; the number of apoptotic cells; and the Mn content and caused obvious histopathological changes in the testes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2013  |  View Paper
Exposure to Mn significantly elevated the content of NO and the expression of iNOS mRNA.
Biological Trace Element Research  •  2013  |  View Paper
These data indicate that near‐physiological concentrations of Mn potentiate cytokine‐induced expression of NOS2 and production of NO in astrocytes via activation of sGC, which promotes ERK‐dependent enhancement of NF‐κB signaling.
Journal of neuroscience research  •  2008  |  View Paper
Pretreatment with nitric oxide blocker (7-nitroindazole, 7-NI), vitamin E or NF-kappaB inhibitor (SN50) significantly protected the cells from Mn and DA interaction-induced reactive oxygen species (ROS) and apoptosis.
Brain Research Bulletin  •  2008  |  View Paper
We previously reported that Mn enhances production of NO in activated astrocytes that promotes apoptosis in cocultured neuronal cells by a mechanism involving the transcription factor nuclear factor‐κB (NF‐κB) (Liu et al., 2005 ).
Journal of neuroscience research  •  2008  |  View Paper
Although microglial cytotoxic mediator-induced neurotoxicity is suggested, the mechanism by which manganese up-regulates cytotoxic mediator, such as nitric oxide (NO), remains poorly understood.
Neuroscience Letters  •  2006  |  View Paper
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