“Here, we show that the calcium antagonist nifedipine upregulates the expression of manganese superoxide dismutase ( Mn SOD), an endogenous antioxidant enzyme, in vascular smooth muscle cells (VSMC) via cellular interactions between VSMC and endothelial cells (EC).”
“We conclude that the calcium antagonist nifedipine induces upregulation of Mn SOD expression in VSMC via NO derived from EC.”