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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Manganese
drug:
Nifedipine
Research Papers that Mention the Interaction
“Here, we show that the calcium antagonist nifedipine upregulates the expression of manganese superoxide dismutase ( Mn SOD), an endogenous antioxidant enzyme, in vascular smooth muscle cells (VSMC) via cellular interactions between VSMC and endothelial cells (EC).”
“We conclude that the calcium antagonist nifedipine induces upregulation of Mn SOD expression in VSMC via NO derived from EC.”
Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathways.“ Nifedipine , an L-type Ca2+ channel blocker, dose dependently inhibited both the contraction and the manganese uptake by the application of 5 mM Mn2+ in the Ca2+-free, 35-60 mM K+ medium.”
Effects of nifedipine on contraction by Mn2+ in Ca2+-free, high-K+ medium in ileal longitudinal muscle.
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