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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Manganese
drug:
Minocycline
Research Papers that Mention the Interaction
“Consistent with the stated hypothesis, minocycline significantly reduced the macrophage number in the lesion site and minimized the TH-IS striatal loss induced by Mn.”
Macrophages-mediated neurotoxic effects of intra-nigral manganese administration are attenuated by minocycline“In Mn-Minocycline and Mn+Minocycline treated flies a significant decrease of MDA levels was detected when compared to the Minocycline group indicating that Minocycline and Mn appear to have a synergistic effect.”
“In conclusion, Minocycline increased the life span and motor activity and decreased MDA formation of manganese treated D. melanogaster, probably by an inhibition of the production of reactive oxygen species.”
“Furthermore, treatment with minocycline , an inhibitor of microglial activation, attenuated microglial activation and mitigated IL-1beta, TNF-alpha, and iNOS production as well as dopaminergic neurotoxicity induced by manganese.”
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