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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Manganese
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Existing data show that interactions occur between Fe and Mn due to certain similarities regarding their mechanisms of the absorption and the transport.”
“In both humans and animals, there is a strong relationship between Fe and Mn metabolism.”
Interactions between iron and manganese in neurotoxicity“In 2017, redox conditions (…) favorable to both Fe … Mn reduction led to an increase (~880%) of dissolved Mn (average for 2015: 66 ± 130 µg L-1; 2017: 582 ± 626 … (~75%, 2015: 547 ± 498 mg kg-1; 2017: 135 ± 80 mg kg-1) in the total Mn content in soils.”
“In 2017, redox conditions (…) favorable to both Fe … Mn reduction led to an increase (~880%) of dissolved Mn (average for 2015: 66 ± 130 μg L−1; 2017: 582 ± 626 … (~75%, 2015: 547 ± 498 mg kg−1; 2017: 135 ± 80 mg kg−1) in the total Mn content in soils.”
“Existing data demonstrate a tight interaction between manganese (Mn) and Fe , especially in Fe-deficient state.”
“The influence of Mn on Fe homeostasis may be mediated through its influence on Fe absorption, circulating transporters like transferrin, and regulatory proteins.”
“In brain of Mn-exposed rats manganese leads to a decreased iron (Fe) concentration, to a shift from Fe(III) to Fe(II) after long term exposure and thus to a shift toward oxidative stress.”
“Combined treatments of Fe with Mn or DA also tended to increase Emx2 expression level.”
“ Mn exposure is known to alter iron (Fe) homeostasis.”
“As a result, we have demonstrated the importance of the interdependence of the transport of Mn and Fe , and established brain metal concentrations in several longitudinal studies.”
“Conversely, when Mn concentrations are altered, the homeostasis and deposition of Fe and other transition metals are disrupted.”
“Previous work from this laboratory has shown that manganese Mn ) exposure alters the function of iron regulatory protein (IRP) and increases iron (Fe) concentrations in the cerebrospinal fluid (CSF).”
“Iron and Mn compete for transport into PC12 cells via DMT1, so removal of iron from the culture media enhances Mn toxicity.”
“In FeD, the addition of 5 mM. iron Fe ) to the Mn perfusate competitively inhibited Mn absorption; conversely Mn reduced Fe absorption.”
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