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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Remarkably, ebselen appears to be highly effective in attenuating the various adverse effects of manganese.”
Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure and Potential Protective Effects of Ebselen in Rats“The above results indicate that Ebs alleviated Mn neurotoxicity via its antioxidant, anti-inflammatory, and anti-apoptotic activities.”
“Co-… with Mn … Ebs or Mn plus PAS caused a significant decrease in blood and brain Mn concentrations (compared to rats treated with Mn alone), concomitant with reduced brain E₂ prostaglandin (PGE₂) and enhanced brain glutathione (GSH) levels, decreased serum prolactin (PRL) levels, and increased ambulation and rearing activities.”
“This hypothesis is supported by the observation that ebselen also regulated the homeostasis of the transition metals Mn , Cu, Fe, and Zn, with increases in transition metal uptake paralleling known induction times for the expression of antioxidant metalloenzymes.”
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