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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Manganese Cation (2+)
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Cd2+, Ni2+, Co2+, Mn2+ , Mg2+ all block Ca currents, as do barbiturates, D-600 and nifedipine.”
Slow calcium and potassium currents in frog skeletal muscle: their relationship and pharmacologic properties“These results are consistent with a Mn2+‐induced inhibition of Na+‐Ca2+ exchange.”
“ Ca2+ (1 mM) enhanced the inhibitory effect of Al3+ (IC50 decreased to 149 muM) but antagonized that of Mn2+ (IC50 = 10 mM) and Cd2+ (IC50 = 2.1 mM).”
“ Calcium ion (3mM) activated soluble guanylate cyclase 3-fold at a relatively low concentration of Mn2+ (less than 1mM) but inhibited the particulate enzyme slightly at all Mn2+ concentrations tested.”
“The reduction of Mn(II) absorption in the roots of indica rice and hybrid rice induced by Ca2+ and Mg2+ was more than that of japonica rice.”
Effects of surface charge and chemical forms of manganese(II) on rice roots on manganese absorption by different rice varieties.“By contrast, Ca decreased the Mn/Fe solids ratio and decreased the fraction of Mn(II) associated with the solids, suggesting that Ca and Mn(II) compete for sorption sites.”
“This is seen by a reduced calcium affinity at its effector site and reduced competition for binding to the Mn(II) site , resulting in acceleration of the initial lagtime by Ca(2+), in contrast to retardation in spinach.”
“The Ca2+ release was inhibited by La3+, Mn2+ , Mg2+, TPP+, and nigericin (in the presence of KCl) and activated by spermine and hypotonicity.”
“E-I and E-II did not depend on metal ions although activity of the latter was slightly stimulated by Mn2+and Ca2+in the range of 0.5-2 mM. At the same concentrations, Mg2+was slightly inhibitory of both enzymes.”
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