Possible Interaction: Manganese and Calcium Supplement

“This epitope was also induced upon EGTA treatment to remove calcium, and the addition of calcium inhibited 9EG7 epitope induction by manganese or by ligand.”

“Plasma Ca uptake was lower when Mn was simultaneously administered, but the results were not significantly different.”

“The addition of Ca as either CaCO3 or 2% milk to the oral Mn essentially blocked the plasma uptake of Mn.”

“These results indicate that the plasma uptake of Mn is greatly reduced by concomitant ingestion of Ca but may be increased by an oral load of Zn.”

“Both Sr 2+ and Mn 2+ effectively displace Ca 2 + from human Factor IX; whereas Mg 2+ is considerably less potent in this regard.”

“Activity in the presence of Mn 2 + was up to several hundred-fold greater than with Mg 2+ and was increased 3–10-fold by Triton X-100.”

“However, we found that Mn exposure was associated with significantly higher reactive oxygen species (ROS) generation in SM compared to CA NPCs despite significantly less intracellular Mn accumulation.”

“ Mn fluxes were decreased by calcium and calcium antagonists, almost 100% inhibited at 4°C, and affected by quinacrine and ouabain.”

“However, a high concentration of manganese partially reverted the inhibitory effect of a high calcium concentration.”

“Cell adhesion was dependent on extracellular divalent cations, a characteristic event of VLA-1 never before shown for IELs: manganese and magnesium ions supported binding in a dose-dependent manner; calcium ions inhibited their effectiveness.”

“Keratinocytes adhered in the presence of magnesium and manganese ions, but calcium ions did not support adhesion and inhibited adhesion when combined with magnesium and manganese.”

“Low iron and calcium levels place the population at higher risk from the massive manganese exposure.”