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Last Updated: 3 years ago
supplement:
Manganese
Research Papers that Mention the Interaction
“Functional studies demonstrated that inhibition of ER stress improves MN survival in vitro even in MNs expressing low SMN.”
“Therefore, our study implies that selective activation of ER stress underlies MN death in SMA.”
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.“Taken together, these data reveal that Mn induces neuronal cell death through ER stress and the UPR response pathway and that this apoptotic effect is potentiated by iron deficiency most likely through upregulation of DMT1.”
“The findings clearly demonstrated that Mn induced the ER stress via activation of PERK and IRE1 signaling pathway, which contributed to the occurrence of apoptosis in cultured slices.”
Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures.“… Mn caused statistically significant (at p ≤ 0.05) and biologically relevant changes in relative abundance (≥2-fold increases or ≥50% decreases) in 322 … predicted to be secretory using three different prediction tools, with more decreasing than increasing (181 and 82, respectively), suggesting that this metal stress causes an … pathways.”
Effects of Excess Manganese on the Xylem Sap Protein Profile of Tomato (Solanum lycopersicum) as Revealed by Shotgun Proteomic Analysis“This study concluded that foliar nutrient distribution in symplastic compartments is a determinant of Mn sensitivity, and that Mn stress hinders plant resistance to biotic stress.”
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