Possible Interaction: Manganese and Ascorbate

“ Ascorbate supplementation increased Fe concentrations in most analyzed tissues, hepatic14C, tissue ascorbate and Mn concentration in the adrenal and testes, but decreased the concentrations of Cu in the kidney and Mn in the spleen.”

“These results indicate that ascorbate and Cr may affect Mn distribution.”

“These data suggest that the disease modifying effect (the ability to retard progression of cartilage degeneration) of a mixture of glucosamine, chondroitin sulfate, and manganese ascorbate is more efficacious than either agent alone.”

“Zinc, Cd and Mn uptakes were depressed by L-ascorbate , dehydroascorbate or EDTA, whereas their transports were enhanced, except for Mn transport which was unaffected by L-ascorbate.”

“Exogenous application of Mn increased ROS detoxification by increasing the content of the phenolic compounds, flavonoids, and ascorbate ( AsA ), and increasing the activities of monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR), superoxide dismutase (SOD), and catalase (CAT) in the salt-treated seedlings.”

“The activities of ascorbate peroxidase, dehydroascorbate reductase and glutathione reductase and the content of reduced ascorbate increased with increasing Mn concentration, while the SOD activity was inhibited significantly at 5 mmol x L(-1) of Mn but enhanced at > or = 10 mmol x L(-1) of Mn.”

“Nitration enhancement by MPs was effectively inhibited by ascorbate, glutathione, or serum, although much higher concentrations of ascorbate were required to inhibit nitration catalyzed by either Mn or Fe tetramethylpyridyl porphyrin.”