Possible Interaction: Malathion and Vitamin C

“Thus, vitamins C and E can reduce malathion hepatotoxicity, although the degree of protection they provide is limited.”

“By the end of 4th week, rats given malathion alone, or in combination with vitamins C and E, had significantly lower sperm counts and sperm motility, and significantly higher abnormal sperm numbers, than the untreated control rats.”

“Genotoxic effect of agriculture-used concentration of organophosphorous pesticide, Malathion , is decreased by the dietary concentration of sodium salt of L-ascorbic acid for parameters like mitotic-index and clastogeny in onion root-tip cells, clastogeny and meiotic-index in mice, and lethal mutation rate in Drosophila melanogaster.”

“Co-administration of malathion 50 mg/kg and ascorbic acid 200 mg/kg significantly decreased the apoptotic cells in both cell types in comparison with malathion 50 mg/kg group (P<0.001).”

“The results of PCNA staining revealed that the proliferation of these cells was … in malathion 50 mg/kg group vs control group (P<0.001), and malathion 50 … plus ascorbic acid 200 mg/kg administration increased the proliferation of cells … with malathion 50 mg/kg group (P<0.001).”

“It was also found that administration of malathion in combination with ascorbic acid reduced MDA level and increased the GSH level.”

“Also, administration of malathion in combination with Ascorbic Acid , reduced MDA level and increased the GSH content in rat ovarian tissue.”