Possible Interaction: Magnesium and Vitamin E

“A … of magnesium (≥380 mg/day) and phylloquinone (500 μg/day) proved protective, as did a serum 25(OH)D concentration of ≥75 nmol/… oxidative damage appears to be a cause of CV calcification, the antioxidant vitamins proved to be largely ineffective, while supplementation of α-tocopherol may … calcification.”

“BACKGROUND Growing attention has been paid to use the combination of magnesium and vitamin E , which might improve metabolic profiles in patients with metabolic diseases.”

“However, the glycemic-improving properties of magnesium and vitamin E co-supplementation were small and may not reach clinical importance.”

“Our meta-analysis indicated that the co-supplementation with magnesium and vitamin E resulted in a significant decrease in FPG, Insulin, HOMA-IR, TG, TC, and LDL-C in comparison with placebo.”

“RESULTS The findings showed that intakes of vi amin E, z inc, and mag nesium in patients were significantly lower and intakes of copper and selenium were significantly higher than RDA (P < 0.05).”

“Furthermore, magnesium plus vitamin E supplementation significantly decreased serum triglycerides (-15.0±24.4 vs. +6.7±22.2 mg/dl, p=0.001) and VLDL-cholesterol concentrations (-3.0±4.9 vs. +0.6±2.4 mg/dl, P=0.01) compared with the placebo.”

“…,magnesium … vitamin E co-supplementation led to a significant reduction in serum insulin levels (-1.1±3.0 vs. +1.6±3.7 μIU/ml, p=…), and a significant increase in the quantitative insulin sensitivity check index (+0.01±0.01 vs. -0.009±0.02, p=0.003).”

“… magnesium … vitamin E supplements decreased triglycerides (β −10.08 mg/dL; 95% CI, −19.70, −0.46; p = 0.04), LDL‐cholesterol (β −5.88 mg/…; p = 0.01) and total antioxidant capacity (TAC) levels (β 53.61 mmol/L; 95% CI, 4.65, 102.57; p = 0.03).”

“… magnesium … vitamin E supplements reduced ulcer length (β [difference in the mean of outcomes measures between treatment groups] −0.56 cm; 95% CI, −0.92, −0.…% CI, −0.64, −0.05; p = 0.02) and depth (β −0.18 cm; 95% CI, −0.33, −0.02; p = 0.02).”

“ Magnesium … vitamin E co-supplementation resulted in a significant reduction in hirsutism (β − 0.37; 95% CI, − 0.70, − 0.05; P = 0.02) and serum …; P = 0.001) and total antioxidant capacity (TAC) levels (β 66.32 mmol/L; 95% CI, 43.80, 88.84; P < 0.001).”

“Synergistic approach of magnesium and vitamin E may benefit clinical symptoms of patients with polycystic ovary syndrome (PCOS) through improving their metabolic profiles and reducing oxidative stress and inflammation.”

“…,magnesium plus vitamin E supplementation resulted in a significant reduction in serum triglycerides (β − 50.31 mg/dL; 95% CI, − 67.58, − 33.04; P < 0.001), … = 0.03) and total-/HDL-cholesterol ratio (β − 0.46; 95% CI, − 0.72, − 0.19; P < 0.001) compared with placebo.”

“Combined use of Vit E and Mg could effectively improve fluidity of erythrocyte membrane.”

“We concluded that preventive supplementation of VE combined with magnesium was more beneficial to improve the plasma lipid parameters and blood viscosity in diabetic rats than magnesium alone.”

“We hypothesized that preventive supplementation of magnesium combined with VE could improve the metabolism of lipids and blood viscosity more effectively than the use of magnesium or VE alone.”

“In comparison to the standard diet, diets with magnesium and vitamin E supplementation resulted in significantly higher magnesium and vitamin E concentrations in plasma and articular cartilage.”

“Supplementation with magnesium and vitamin E alone or in combination may relevantly diminish joint cartilage lesions induced by quinolones in immature rats, with an additive effect of combined supplementation.”