Possible Interaction: Magnesium and Vitamin D

“Indeed, magnesium is important for activating vitamin D and has a protective role against oxidative stress.”

“There is an important functional link between magnesium and calciotropic hormones.”

“ Mg is necessary for the biosynthesis, transport, and activation of vitamin D , another key factor in the pathogenesis of infectious diseases.”

“Conclusion Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation for a duration of 8-weeks could improve the behavioral function and mental health of children with ADHD.”

“… vitamin D … magnesium showed a significant reduction in emotional problems ( p = 0.001), conduct problems ( p = 0.002), peer problems ( p = 0.001), prosocial score ( p = …), total difficulties ( p = 0.001), externalizing score ( p = 0.001), and internalizing score ( p = 0.001) compared with children treated with the placebo.”

“ Magnesium plays a critical role in vitamin D biosynthesis and metabolism; and deficiencies in magnesium and vitamin D show associations with poor cognition.”

“The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (p < 0.05).”

“ Mg is essential in the metabolism of vitamin D , and taking large doses of vitamin D can induce severe depletion of Mg.”

“In men, pork and beef; squid, octopus, shrimp, and clams; eggs; mushrooms; Japanese-style sweets; ice cream; bread; …, animal fat, carbohydrate, monounsaturated fatty acid, polyunsaturated fatty acid (PUFA), n-3 PUFA, n-6 PUFA, cholesterol, vitamin D, …, magnesium , phosphorus, and zinc as nutrients significantly … interaction <0.05 for all).”

“ Vitamin D supplementation improves serum concentrations of magnesium and selenium in a gender-dependent manner, which in turn could affect several cardiometabolic parameters such as glucose and lipids.”

“Intake of magnesium significantly interacted with intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency.”