“Locally applied tramadol (0.125 mg/paw) better reduced edema (50–… (20–50%) during 24 h. Administration of a fixed dose of tramadol (1.25 mg/… doses of magnesium led to a dose-dependent enhancement and prolongation of the … of tramadol both in prevention and treatment of inflammatory pain.”
“ Magnesium increases the antiedematous effect of tramadol in the prevention of inflammatory edema while reducing it in treatment.”