Possible Interaction: Magnesium and Thiamine

“RESULTS The acute combined administration of Zn, Mg a nd Vit B1 si gnificantly decreased immobility time in FST, increased the percentage of both time spent in- and entries to open arms in the elevated plus-maze, and augmented TAC.”

“As magnesium is an essential co-factor in the conversion of thiamine into active diphosphate and triphosphate esters, functional thiamine deficiency may be contributory.”

“One recent study confirmed a significant increase of the activity of erythrocyte transketolase in the group treated with magnesium and thiamine compared to the group that received thiamine only, which means that the administration of magnesium plus thiamine may speed up the recovery of metabolic pathways.”

“Previous literature identifies magnesium as an important cofactor in thiamine utilisation, which might also be compromised in alcohol dependent patients.”

“Much has been written about the association of thiamin and magnesium but the finding of extremely high concentrations of serum thiamin in SIDs victims has largely caused rejection of thiamin as being involved in the etiology.”

“This case report emphasizes the dependence of thiamine on magnesium for an adequate function in the body.”

“It may be conceivable that endogenous magnesium excretion is enhanced by thiamine administration in sheep.”

“This suggests that magnesium plays a considerable role in the maintenance of thiamine in tissues.”

“ Mg supplementation increased the antioxidant activity of the fruiting bodies, phenolic compounds, and some amino acids, including L-tryptophan, and vitamins ( thiamine and l-ascorbic acid).”