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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Magnesium
drug:
Tetracycline
Research Papers that Mention the Interaction
“Consequently the action of a drug may … adversely affected by magnesium (e.g., magnesium , calcium, and zinc can interfere with the gastrointestinal absorption of tetracycline antibiotics ) and simultaneously the physiological function of minerals such as magnesium may be impaired by a drug (e.g., diuretics induce renal magnesium loss).”
Magnesium and Drugs“The concomitant administration of magnesium trisilicate with tetracycline hydrochloride resulted in a dramatic reduction of the excretion rate of the drug.”
“To the Editor.— Concerning the interaction of antibiotics with other drugs (219:206, 1972), Kabins is correct in stating that gastrointestinal binding of tetracycline with polyvalent cations (aluminum, calcium, and magnesium ) may decrease the absorption of the antibiotic.”
“Addition of calcium and magnesium to the buffer greatly reduced the transfer of tetracycline ; this inhibition could be antagonized by EDTA.”
The transport of tetracyclines across the mouse ileum in vitro: the effect of cations and other agents“ Tetracycline MICs were increased 1.2- to 6.5-fold when the concentration of magnesium or calcium was ≥10 mM. The results of this in vitro study might provide insight into the effects of local in vivo environmental conditions on several classes of antimicrobial agents.”
The Effects of Environmental Conditions on the In Vitro Activity of Selected Antimicrobial Agents Against Escherichia coli
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