Possible Interaction: Magnesium Sulfate and Magnesium Cation

“ Intravenous magnesium sulfate infusion significantly increased plasma ionized magnesium concentration (peak, 0.89 ± 0.11 mmol/L), but CSF magnesium levels did not change during the 4-hour study.”

“The primary effectiveness outcome, achievement of target serum magnesium concentration (≥2 mEq/L) compared to expected achievement using a “rule of thumb” estimation that 1 g intravenous magnesium sulfate raises the magnesium concentration 0.15 mEq/L, was tested using 1-sample z test.”

“The serum concentration of magnesium ions after administration of MgSO4 40 mg was significantly higher than that after 20 mg.”

“ Intravenous magnesium sulfate significantly increased the iMg2+ level in patients in group L from 0.35 +/- 0.06 mmol/L (mean +/- SD) to 0.54 +/- 0.09 mmol/L (p < 0.01), and had an antiarrhythmic effect in 7 of the 8 patients (88%).”

“After injection of MgSO4 solution, the cerebrospinal fluid magnesium ion concentration significantly increased to 3.89 ± 0.97 mEq/L (P < 0.01) from the baseline value (1.49 ± 0.07 mEq/L).”

“A bolus dose of magnesium sulphate (MgSO4) 30, 60 and 90 mg kg-1 significantly increased plasma magnesium concentrations from 1.3 (SEM 0.1) to 15.3 (1.3) mg dl-1.”

“In this …, MgSO4 diminishes the electrostatic long-distance attractive interactions between the oxidized … and the charged headgroups of the interface, owing to the Mg+2 and SO4-2 screening effects and an electrostatic stabilization of the headgroups, … the pore formation, which is well-known to occur in oxidized membranes.”

“Recently, however, we have found (2) that some of the anions which we were inadvertently introducing in the earlier work (e.g. in varying the concentration of Mg++ with the use of magnesium sulfate ) strongly interact with this enzyme system, thereby confusing attempts at kinetic interpretation.”