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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Magnesium Sulfate
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Experimental studies suggested that MgSO4 inhibits excitatory amino acid release, blocks N-methyl-D-aspartate (NMDA) receptors and prevents calcium entry into the cell.”
Magnesium therapy within 48 hours of an aneurysmal subarachnoid hemorrhage: neuro-panacea“ Magnesium sulfate decreased inositol trisphosphate production in calcium-containing media but had no additional effect in calcium-free media.”
“Using a novel ion‐selective electrode, we have shown that there is over a 100% increase in venous serum levels of ionized Mg during intravenous MgSO4 therapy of preeclamptic patients.”
“Similarly, magnesium sulphate , which acts by preventing an increase in intracellular calcium , is rarely used.”
“Urinary losses of calcium in the magnesium sulfate group , approximately 800 to 900 mg/day, were substantial.”
“Urinary output of magnesium, calcium , and copper was significantly greater in the magnesium sulfate group than in the control group throughout the study.”
“ Urinary calcium concentration increased 4.5-fold during magnesium sulfate infusion, and the urinary calcium excretion rate was 3 times that observed in controls.”
“Addition of a dose of magnesium sulphate to the infusion antagonises the effect of gastric acid secretion caused by calcium.”
“Patients receiving MgSO4 (1 or 2 gm) had increases in Mg+ + and reduction of Ca++ and K+ even when muscle fasciculations were evident.”
“These results suggest that magnesium sulfate hardly affects the electrical vulnerability of the heart during haloperidol overdose, but may block the calcium , potassium and sodium channels, which may explain its antiarrhythmic action.”
Effect of magnesium sulfate on the haloperidol-induced QT prolongation assessed in the canine in vivo model under the monitoring of monophasic action potential.“In addition, the limb rigidity that accompanies this increase in calcium was prevented by MgSO4 pretreatment.”
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