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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Magnesium
drug:
Sugammadex
Research Papers that Mention the Interaction
“The authors investigated whether magnesium decreased the efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular block.”
Efficacy of Sugammadex for the Reversal of Moderate and Deep Rocuronium-induced Neuromuscular Block in Patients Pretreated with Intravenous Magnesium: A Randomized Controlled Trial“ Magnesium decreases the safety margin of reversal of rocuronium-induced neuromuscular block with sugammadex.”
“We investigated whether the potentiation of rocuronium-induced blockade by magnesium reduces the effect of sugammadex in an ex-vivo environment and how this influences the safety margin of reversal.”
“… magnesium from 1 mM …% CI) EC50 of sugammadex from 3.67 μM (3.43–3.92 μM) to 5.36 μM (5.18–5.53 μM), whereas mean (95% ….22 μM (6.09–8.54 μM) and 7.61 μM (7.05–8.20 μM), respectively (p = 0.542).”
The effect of magnesium on the reversal of rocuronium-induced neuromuscular block with sugammadex: an ex vivo laboratory study
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