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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Magnesium
drug:
Rocuronium
Research Papers that Mention the Interaction
“BACKGROUND Magnesium is known to enhance the effect of rocuronium , but the extent is not quantified.”
“BACKGROUND Magnesium is known to enhance the effect of rocuronium , but the extent is not quantified.”
“CONCLUSION Ma nesium re duced the dose of roc uronium re quired for deep neuromuscular blockade by approximately 20% without affecting the recovery time after administration of sugammadex.”
“CONCLUSION Magnesium reduced the dose of rocuronium required for deep neuromuscular blockade by approximately 20% without affecting the recovery time after administration of sugammadex.”
“RESULTS The dose of ro uronium ad ministered to maintain deep neuromuscular blockade was significantly lower in the mag nesium group (7 .5 vs. 9.4 μg kg min, P = 0.01).”
“RESULTS The dose of rocuronium administered to maintain deep neuromuscular blockade was significantly lower in the magnesium group (7.5 vs. 9.4 μg kg−1 min−1, P = 0.01).”
Effects of magnesium on the dose of rocuronium for deep neuromuscular blockade: A randomised controlled trial.“Specifically, the authors state that “desflurane and a small fraction of unbound rocuronium may have amplified the known muscle relaxing effects of magnesium”.”
“When rocuronium is used to facilitate general endotracheal anesthesia in a patient for emergency cesarean delivery, it is important to recognize that magnesium may prolong neuromuscular block significantly.”
“Background Magnesium enhances the effect of rocuronium.”
“It is important to remember that magnesium potentiates the effects of all non-depolarizing neuromuscular blocking agents, including rocuronium.”
“The expected duration for neuromuscular block of rocuronium in the absence of magnesium would be approximately 53 min; with infusion of magnesium , the duration of neuromuscular block was prolonged four-fold (215 min).”
“ResultsThe mean (95% confidence interval [CI]) half effective concentrations (EC50) of rocuronium in the presence of magnesium 1 mM or 1.5 mM were 7.50 μM (6.97–8.07 μM) and 4.25 μM (4.09–4.41 μM), respectively (p < 0.0001).”
The effect of magnesium on the reversal of rocuronium-induced neuromuscular block with sugammadex: an ex vivo laboratory study“ Magnesium enhances the neuromuscular block of rocuronium.”
Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits“This study investigated the efficacy and safety of NM block caused by the administration of high concentrations of magnesium in combination with ropivacaine, gentamicin, and rocuronium.”
“Results Compared to saline, 10 and 20 mg/kg of magnesium significantly reduced the incidence of overall movement after rocuronium injection (34% and 36% in group 3 and 4, respectively vs. 76% in the group 1) (P < 0.0001).”
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