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Last Updated: 2 years ago

Possible Interaction: Magnesium and Rocuronium

supplement:

Magnesium

Research Papers that Mention the Interaction

BACKGROUND Magnesium is known to enhance the effect of rocuronium , but the extent is not quantified.
BACKGROUND Magnesium is known to enhance the effect of rocuronium , but the extent is not quantified.
CONCLUSION Ma nesium re duced the dose of roc uronium re quired for deep neuromuscular blockade by approximately 20% without affecting the recovery time after administration of sugammadex.
CONCLUSION Magnesium reduced the dose of rocuronium required for deep neuromuscular blockade by approximately 20% without affecting the recovery time after administration of sugammadex.
RESULTS The dose of ro uronium ad ministered to maintain deep neuromuscular blockade was significantly lower in the mag nesium group (7 .5 vs. 9.4 μg kg min, P = 0.01).
RESULTS The dose of rocuronium administered to maintain deep neuromuscular blockade was significantly lower in the magnesium group (7.5 vs. 9.4 μg kg−1 min−1, P = 0.01).
European journal of anaesthesiology  •  2020  |  View Paper
Specifically, the authors state that “desflurane and a small fraction of unbound rocuronium may have amplified the known muscle relaxing effects of magnesium”.
Acta anaesthesiologica Scandinavica  •  2015  |  View Paper
When rocuronium is used to facilitate general endotracheal anesthesia in a patient for emergency cesarean delivery, it is important to recognize that magnesium may prolong neuromuscular block significantly.
Masui. The Japanese journal of anesthesiology  •  2014  |  View Paper
It is important to remember that magnesium potentiates the effects of all non-depolarizing neuromuscular blocking agents, including rocuronium.
The expected duration for neuromuscular block of rocuronium in the absence of magnesium would be approximately 53 min; with infusion of magnesium , the duration of neuromuscular block was prolonged four-fold (215 min).
British journal of anaesthesia  •  1996  |  View Paper
ResultsThe mean (95% confidence interval [CI]) half effective concentrations (EC50) of rocuronium in the presence of magnesium 1 mM or 1.5 mM were 7.50 μM (6.97–8.07 μM) and 4.25 μM (4.09–4.41 μM), respectively (p < 0.0001).
BMC Anesthesiology  •  2019  |  View Paper
Magnesium enhances the neuromuscular block of rocuronium.
Korean journal of anesthesiology  •  2017  |  View Paper
This study investigated the efficacy and safety of NM block caused by the administration of high concentrations of magnesium in combination with ropivacaine, gentamicin, and rocuronium.
Korean journal of anesthesiology  •  2015  |  View Paper
Results Compared to saline, 10 and 20 mg/kg of magnesium significantly reduced the incidence of overall movement after rocuronium injection (34% and 36% in group 3 and 4, respectively vs. 76% in the group 1) (P < 0.0001).
Korean journal of anesthesiology  •  2011  |  View Paper