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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Magnesium
drug:
Potassium Chloride
Research Papers that Mention the Interaction
“The concentration of magnesium was significantly lower in the potassium chloride substitution group (1.48 mmol/l) compared to the other group (2.33 mmol/l) (p < 0.05).”
[Potassium substitution during coronary surgery: K(+)-Mg+(+)-aspartate-complex (Inzolen) versus potassium chloride].“In rat aortic rings incubated in plasma from pregnant patients, magnesium was more potent in relaxing the precontractions induced by potassium chloride than in relaxing those induced by phenylephrine.”
“Also, the ED50 for KCl was higher for preeclamptics given magnesium (12.45 +/- 1.21 mM) compared to controls (9.17 +/- 1.05 mM).”
“High magnesium significantly decreased the KCl and Phe-induced constriction and increased the ACh-induced dilation response of the mesenteric arteries in the hypertensive group, while it did not alter these responses in controls.”
Effect of magnesium on vascular reactivity in NOS inhibition-induced hypertension.“Higher concentrations of magnesium in the perfusate attenuated the vascular responses to norepinephrine and potassium chloride in a dose-related manner.”
“The attenuating effect of magnesium on the responses to norepinephrine and to potassium chloride were reversed by elevation of calcium concentration in the perfusate.”
“These results indicate that magnesium acts antagonistically on calcium movement in vascular contractions due to potassium chloride , but that the relationship between magnesium and calcium is more complex in vascular contractions induced by norepinephrine.”
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