Possible Interaction: Magnesium and Polymyxin B

“This report describes the case of a patient prescribed polymyxin B to treat a surgical wound infection, which led to significant increases in fractional excretion of calcium, magnesium , and potassium and subsequent persistent decreases in the levels of these ions, with serious consequences for the patient.”

“On additional reduction of the intracellular magnesium concentration from 100 to 50 mM by adding the antibiotic polymyxin B to the infected cells, T4 infections, but not T3 or T7, were markedly affected.”