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“The results revealed that Mg regulates the expression of organic cation transporter 2, multidrug and toxin extrusion protein 1, and copper transporter 1, leading to reduced renal platinum accumulation, which results in CIN attenuation.”
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan • 2020 | View Paper
“Conclusion: Mg co‐administration significantly attenuated CIN by reducing renal platinum accumulation even after multiple rounds of treatment with CDDP as effectively as in a model of a single CDDP administration.”